Overview

Preparing for healthier superannuation

Alzheimer disease is a brain disease that brings gradual degradation of memory, and results in dementia
after severe intelligence loss as to not be able to continue everyday life. Alzheimer Dementia consists of
75% of all dementia and there are 36 million patients worldwide.¹ In most cases Alzeheimer induced
Dementia occurs around 65 years of age, but in rare cases, may happen before that.

Alzheimer’s Disease has a very high inheritance rate. Even in the cases of late-onset, the inheritance rate is
60~80%.² For example, APOE is a gene that allows for the certainty, and can be used to explain 20% of all
Alzheimer diseases.³ But not everyone contracts Alzheimer disease due to family history, as there are
environmental factors such as eating habits, and life style choices.

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Overview 이미지

What is a Alzheheimer RISK ?

Early recognition can postpone it

Alzheheimer RISKis a DNA chip based diagnostics test that analyzes DNA extracted from blood to
estimate the risk of contracting Alzheimer’s disease.

We have made a predictive model from the well-documented and frequent genes associated with Alzheimer
and tested on Korean population to do a retrospective risk prediction and classification of high-risk group.
There isn’t any method of complete treatment but there exists a symptom-alleviating treatment.⁴and
therefore, prevention is absolutely needed. Alzheheimer RISKscreens high-risk group to allow for healthier
old age through prevention and management.

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Detectable Diseases

Only one test to predict the risk of Alzheimer induced Dementia risk

is a prediction test for Alzheimer induced risk. 3 out of 4 dementia
patients with age 65 or more is from Alzeheimer’s Disease and the number is increasing.

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To whom is the test useful to?

Know your risk 검사대상 이미지
  • Anyone whose direct family has Alzheimer’s.
  • Anyone who wish to know the risk of Alzheimer and manage risk properly

Test Procedure

SD Genomics is a reliable genetic testing service company

SD Genomics performs genetic tests to the requests of medical institutes following the Bioethics and Safety Act. Prior to service request,
understanding the objective of the test, reporting method of the test, and limitations of the test is necessary.

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Hospital
Draw Blood at the hospital.
The Test receives information and fills out the
‘Genetic Test Consent’ form.
The hospital’s staff fills out “Genetic Test Request
form”.
SD Genomics
SD Genomics receives the samples and required
forms.
SD genomics performs the requested test and
analyzes its results.
SD Genomics fills out the test report and sends it
Hospital
After receiving the report, the hospital dose the
genetic counselling.

Test info

Specimen
requirement
  • Whole blood (3-5 cc EDTA tube)
  • DNA 5 - 10 ug TE buffer(min. density 50 ng/uL, A260/A280 ratio: 1.65-2.0)
Sample Logistics
  • Whole Blood or DNA 15-30 ℃ room temperature(within 24 hours) 2-8 ℃ refrigerated
Required Documents Test Requirement and Consent form (provided below)
TAT Within 4-6 weeks
Report Criteria coming

Resources

References
1. Association As. 2014 Alzheimer’s Disease Facts and Figures. Alzheimer’s and Demaentia 2014; 10:e47-e92
2. Gatz M, Reynolds CA, Fratiglioni L, et al. Role of genes and environments for explaining Alzheimer disease. Arch Gen Psychiatry 2006;
3. Ertekin-Taner N. 2010. Genetics of Alzheimer’s disease in the pre- and post- GWAS era. Alzheimers Res Ther 2(1):3.
4. David C. Hsu et al, Primary and Secondary Prevention Trials in Alzhimer’s Disease: Looking Back, Moving Forward, Curr Alzheimer Res. 2017; 14(4):426-440